Viral Amyloids Across Scales

My Structural Biology Journey

Publications


Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture


Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L. Thienel, Beate M. Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera

Nature Communications, vol. 15, 2024, p. 8106


EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control


Olivier Gemin, Victor Armijo, Michael Hons, Caroline Bissardon, Romain Linares, Matthew W. Bowler, Gerd Wolff, Keno Kovalev, Anastasiia Babenko, Ville T. Salo, Sarah Schneider, Christopher Rossi, Léa Lecomte, Thibault Deckers, Kévin Lauzier, Robert Janocha, Franck Felisaz, Jérémy Sinoir, Wojciech P. Galej, Julia Mahamid, Christoph W. Müller, Sebastian Eustermann, Simone Mattei, Florent Cipriani, Gergely Papp

bioRxiv, 2024


A duplex structure of SARM1 octamers stabilized by a new inhibitor


Tami Khazma, Yarden Golan-Vaishenker, Julia Guez-Haddad, Atira Grossman, Radhika Sain, Merav Weitman, Ariel Plotnikov, Ran Zalk, Avraham Yaron, Michael Hons, Yarden Opatowsky

Cellular and Molecular Life Sciences, vol. 80, 2023, p. 16


Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores


Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño Fernandez, Rocio Arranz, Juan Reguera

Proceedings of the National Academy of Sciences of the USA, vol. 120, 2023, pp. e2213934120


Structural basis for the toxicity of Legionella pneumophila effector SidH


Rahul Sharma, Michael Adams, Simonne Griffith-Jones, Tobias Sahr, Laura Gomez-Valero, Felix Weis, Michael Hons, Sarah Gharbi, Rajaa Berkane, Andreas Stolz, Carmen Buchrieser, Sagar Bhogaraju

Nature Communications, vol. 14, 2023, p. 7068


Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans


Tami Khazma, Atira Grossman, Julia Guez-Haddad, Chuan-Wei Feng, Harsh Dabas, Radhika Sain, Merav Weitman, Ariel Plotnikov, Ran Zalk, Michael Hons, Avraham Yaron, Yarden Opatowsky

Cell Reports, vol. 42, 2023, p. 113026


Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface


Mathilde Lethier, Karine Huard, Michael Hons, Adrien Favier, Bernhard Brutscher, Elisabetta Boeri Erba, Derek W. Abbott, Stephen Cusack, Erika Pellegrini

Life Science Alliance, vol. 6, 2023, pp. e202201784


Structure of the human heparan sulfate polymerase complex EXT1--EXT2


Francisco Leisico, Juneina Omeiri, Christine Le Narvor, Joël Beaudouin, Michael Hons, Daphna Fenel, Guy Schoehn, Yohann Couté, David Bonnaffé, Rabia Sadir, Hugues Lortat-Jacob, Rebekka Wild

Nature Communications, vol. 13, 2022, p. 7110


Assembly of the mitochondrial complex I assembly complex suggests a regulatory role for deflavination


Gabriele Giachin, Matthew Jessop, Romain Bouverot, Samira Acajjaoui, Melissa Saïdi, Anaïs Chretien, Maria Bacia-Verloop, Luca Signor, Philippe J. Mas, Adrien Favier, Eve Borel Meneroud, Michael Hons, Darren J. Hart, Eaazhisai Kandiah, Elisabetta Boeri Erba, Alain Buisson, Gordon Leonard, Irina Gutsche, Montserrat Soler-Lopez

Angewandte Chemie International Edition, vol. 60, 2021, pp. 4689--4697


Structural basis for SARM1 inhibition and activation under energetic stress


Michael Sporny, Julia Guez-Haddad, Tami Khazma, Avraham Yaron, Moshe Dessau, Yoel Shkolnisky, Carsten Mim, Michail N. Isupov, Ran Zalk, Michael Hons, Yarden Opatowsky

eLife, vol. 9, 2020, pp. e62021


3D structure of the natural tetrameric form of human butyrylcholinesterase as revealed by cryoEM, SAXS and MD


Konstantin M. Boyko, Timur N. Baymukhametov, Yury M. Chesnokov, Michael Hons, Sofya V. Lushchekina, Petr V. Konarev, Alexey V. Lipkin, Alexandre L. Vasiliev, Patrick Masson, Vladimir O. Popov, Michail V. Kovalchuk

Biochimie, vol. 156, 2019, pp. 196--205


CM01: a facility for cryo-electron microscopy at the European Synchrotron


Eaazhisai Kandiah, Thierry Giraud, Alejandro de Maria Antolinos, Fabien Dobias, Gregory Effantin, David Flot, Michael Hons, Guy Schoehn, Jean Susini, Olof Svensson, Gordon A. Leonard, Christoph Mueller-Dieckmann

Acta Crystallographica Section D: Structural Biology, vol. 75, 2019, pp. 528--535


RIP2 filament formation is required for NOD2 dependent NF-$\kappa$B signalling


Erika Pellegrini, Ambroise Desfosses, Arndt Wallmann, Walter M. Schulze, Katharina Rehbein, Philippe Mas, other

Nature Communications, vol. 9, 2018, p. 4043


Topology and structure of an engineered human cohesin complex bound to Pds5B


Michael T. Hons, Pim J. Huis in 't Veld, Jan Kaesler, Pieter Rombaut, Alexander Schleiffer, Franz Herzog, Holger Stark, Jan-Michael Peters

Nature Communications, vol. 7, 2016, p. 12523


Pan-selective aptamers for the family of small GTPases


Michael Hons, Björn Niebel, Nora Karnowski, Benjamin Weiche, Michael Famulok

ChemBioChem, vol. 13, 2012, pp. 1433--1437